Dimethyladenosine Transferase 1 Like Protein (DIMT1L)

By searching EST databases using S. cerevisiae ORFs, Stanchi et al. (2001) identified DIMT1L, which they called HUSSY5. The deduced 157-amino acid protein shares 57% identity with yeast Dim1.By radiation hybrid analysis, Stanchi et al. (2001) mapped the DIMT1L gene to chromosome 8p12.Transcription factor B1 (TFB1M) is a part of this transcription complex.By sequence analysis of the genomic DNA directly upstream from TFB1M, McCulloch et al. (2002) identified putative binding sites for several nuclear transcription factors, including 2 sites for nuclear respiratory factor-2, which activates the transcription of several nuclear-encoded mitochondrial proteins.