Epoxide Hydrolase 2, Cytoplasmic (EPHX2)

EPHX2 encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.The coding sequence corresponded to 555 amino acids, which the authors noted included 1 additional residue compared to the reported cDNA sequence. Putative sites for phosphorylation, myristoylation, amidation, and peroxisomal targeting, as well as a leucine zipper, were detected.