Epoxide Hydrolase 3 (EPHX3)

The methylation level of alpha-beta hydrolase containing ABHD9 has been identified as predictive marker for prostate cancer.4 ABHD9 is an epoxide hydrolase (EPHX3) with unknown physiological function. Epoxide hydrolase (also known as epoxide hydratase) functions in detoxication during drug metabolism. It converts epoxides to trans-dihydrodiols, which can be conjugated and excreted from the body. Epoxides result from the degradation of aromatic compounds.Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.