Fructose-1,6-Bisphosphatase 2 (FBP2)

Fructose-1,6-bisphosphatase (fru-1,6-P2ase, EC 3.1.3.11) catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate, thus providing a mechanism to permit the reversal of the glycolysis reaction catalyzed by 6-phosphofructo-1-kinase.Tillmann and Eschrich (1998) stated that human liver and muscle fru-1,6-P2ases appear to be distinct enzymes since they differ significantly in their kinetic properties, and no reduction of fru-1,6-P2ase activity was found in muscle in patients with hereditary liver fru-1,6-P2ase deficiency.The predicted 339-amino acid muscle fru-1,6-P2ase shares 77% protein sequence identity with the liver enzyme. Recombinant enzyme had fru-1,6-P2ase activity in vitro.