GTPase, IMAP Family, Member 2 (GIMAP2)

By searching a sequence database using IMAP1 as probe, Stamm et al. (2002) identified IMAP2. The deduced 337-amino acid protein contains 5 motifs conserved in GTP-binding proteins and a putative C-terminal transmembrane region. IMAP2 shares 43% amino acid identity with IMAP1.Stamm et al. (2002) determined that the IMAP1 gene contains 3 exons. Exon 1 is untranslated, and exon 3 contains more than 94% of the coding sequence.By genomic sequence analysis, Stamm et al. (2002) mapped the IMAP2 gene to a 100-kb IMAP gene cluster on chromosome 7q32-q36. Within this cluster, IMAP1 is located on the negative strand, while IMAP2, IMAP3 (IAN4L1), and IMAP4 are on the opposite positive strand.