Gamma-Glutamyltransferase Light Chain 1 (gGTLC1)

gGTLC1 encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified.The deduced 225-amino acid protein is homologous to a small portion of the heavy chain and to the entire light chain of GGT1. Northern blot analysis detected an approximately 1.2-kb transcript in lung only. In vitro translation resulted in a protein with an apparent molecular mass of 24 kD.