Gamma-Glutamyltransferase Light Chain 3 (gGTLC3)

Gamma-glutamyltransferase-1 (GGT1) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region. GGTLC3 encodes a protein corresponding to the GGT1 light chain only, contains residues corresponding to 7 of the 8 glutamate-binding residues in the GGT1 light chain, but it lacks a residue equivalent to arg107 in the GGT1 heavy chain..