Glucose-6-Phosphatase, Catalytic 2 (G6PC2)

G6PC2 encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. The deduced 355-amino acid protein contains 9 major hydrophobic stretches, 8 of which may span the membrane as an alpha helix, and a C-terminal ER membrane retention motif. It also has 3 potential N-glycosylation sites, 1 of which, located in the putative second luminal domain, is conserved with mouse Igrp.