Glutathione S Transferase Mu 3, Brain (GSTm3)

In brain extracts, Van Cong et al. (1984) observed a novel GST band (GST5, or GSTM3) which is probably controlled by an independent gene. By immunoblotting, Campbell et al. (1990) identified GSTM3, a mu-class GST with an isoelectric point of 5.2. GSTM1 is prevalent in testis and found in cerebral cortex but not liver. Campbell et al. (1990) detected GSTM3 in all 13 testes and 28 brain samples tested, including those from individuals devoid of GSTM1 because of a GSTM1 gene deletion. These authors cloned GSTM3 cDNAs from human brain and testis cDNA libraries. The predicted 225-amino acid protein shares 72% sequence similarity with GSTM1.