Glutathione S Transferase Omega 2 (GSTo2)

The omega class glutathione transferases (GST) have poor activity with common GST substrates, but exhibit novel glutathione-dependent thioltransferase, dehydroascorbate reductase, and monomethylarsonate reductase activities, and they modulate Ca(2+) release by ryanodine receptors.By sequencing a chromosome 10 BAC contig containing the GSTO1 gene, Whitbread et al. (2003) identified GSTO2. The deduced 243-amino acid protein shares 64% identity with GSTO1. Northern blot analysis detected a 2-kb GSTO2 transcript highly expressed in testis, and a 1.26-kb GSTO2 transcript highly expressed in liver, kidney, and skeletal muscle, with lower expression in heart and reproductive tissues, predominantly testis, cervix, ovary, and prostate.