Glycerol-3-Phosphate Dehydrogenase 1 (GPD1)

Hopkinson et al. (1974) presented evidence that glycerol-3-phosphate dehydrogenase (EC 1.1.1.8) is a dimer of dissimilar subunits. Electrophoretic variants at each of 2 loci, designated GPD1 and GPD2, were described.Menaya et al. (1995) cloned and sequenced a cDNA encoding a human liver NAD-dependent alpha-glycerol-3-phosphate dehydrogenase. The 1,050-bp open reading frame encodes a 349-amino acid protein of 37.5 kD. Northern blot analysis showed 3 transcripts from human liver and 2 from human placenta. By the method of somatic cell hybridization, Kielty and Povey (1982) assigned the presumed structural gene for alpha-glycerophosphate dehydrogenase to chromosome 12. Prasad et al. (1997) demonstrated that the GPD1 gene maps to chromosome 12q12-q13.