Guanylate Cyclase 1 Alpha 2 (GUCY1a2)

Soluble guanylyl (or guanylate) cyclases are heterodimeric enzymes consisting of an alpha subunit, such as alpha-2 (GUCY1A2), and a beta subunit, typically beta-1 (GUCY1B3), which are activated by nitric oxide (NO) and which catalyze conversion of GTP to 3-prime, 5-prime-cyclic GMP and pyrophosphate.The cDNA encodes a predicted 732-amino acid protein that has regions of high similarity to the alpha-1 (GUCY1A3) sequence.highest expression of the alpha-2/beta-1 isoform was in brain, with significant expression in lung and lower expression in all other tissues examined. Levels of the alpha-1/beta-1 and alpha-2/beta-1 isoforms were comparable in brain, but alpha-1/beta-1 was the predominant isoform in all other tissues examined. Overall, lung had the highest amount of NOGC content.