Guanylate Cyclase 2E (GUCY2E)

The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2). NPR3 encodes a protein with only the ligand-binding transmembrane, and 37-amino acid cytoplasmic domains. Gucy2d is specifically expressed in a subpopulation of olfactory sensory neurons. The rat and mouse Gucy2d genes are homologs of human GUCY2E. In the human, GUCY2E is a transcribed pseudogene