Histone Deacetylase 11 (HDAC11)

Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.The deduced 347-amino acid protein has a calculated molecular mass of 39 kD and contains 9 deacetylase motifs shared by both class I and class II HDACs. The putative catalytic core region includes invariant active site residues shared by eukaryotic HDACs. Northern blot analysis revealed a 1.7-kb transcript, corresponding to the 347-amino acid protein, and a more abundant 3.2-kb transcript. Expression was highest in brain, heart, skeletal muscle, and kidney. Real-time PCR also revealed high expression of HDAC11 in testis. HDAC11 partitioned with nuclear extracts following cell fractionation of transfected 293 cells.