Inositol Polyphosphate Phosphatase Like Protein 1 (INPPL1)

INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.SHIP2 encodes a 1,258-amino acid protein with a predicted molecular mass of 142 kD. SHIP2 was also expressed in dog thyroid cells in primary culture, where the expression was enhanced in thyroid-stimulating hormone (TSH)- and epidermal growth factor (EGF)-stimulated cells.The SHIP2 antiserum precipitated a protein of approximately 145 kD, along with an activity which hydrolyzed phosphatidylinositol 3,4,5-triphosphate to phosphatidylinositol 3,4-bisphosphate. Tyrosine phosphorylation of SHIP2 occurred in response to treatment of cells with EGF, platelet-derived growth factor (PDGF), nerve growth factor (NGF), insulin-like growth factor-1 (IGF1), or insulin.