Janus Kinase And Microtubule Interacting Protein 1 (JAKMIP1)

MARLIN1 interacts strongly with GABBR1 and that the 2 proteins colocalize in the same subpopulation of neurons in the cortex and hippocampus of the rat brain. Further study showed that MARLIN1 was more prominent in the central region of the cell body and in proximal segments of neuronal projections. It formed discrete granules in hippocampal neurons grown in cell culture. The deduced 626-amino acid human protein contains 3 coiled-coil regions, 2 of which include predicted leucine zipper motifs. The protein shares 95 to 98% sequence identity with the rat and mouse orthologs. Northern blot analysis of rat tissues detected abundant expression in brain and moderate expression in testis. Immunoblot analysis demonstrated an approximately 80-kD human protein.