Janus Kinase And Microtubule Interacting Protein 2 (JAKMIP2)

NECC1 encodes a deduced 820-amino acid protein that shares 99% and 88% sequence identity with the mouse and frog homologs. NECC1 contains 7 predicted coiled-coil domains, which span most of the sequence, and a 19-amino acid C-terminal transmembrane domain. A second isoform of NECC1 results from alternative splicing of exon 20 and lacks the transmembrane domain. Fluorescence microscopy localized the NECC1 and NECC2 proteins to the distal compartments of the Golgi complex. NECC1 and NECC2 were expressed at highest levels in the central nervous system and in endocrine tissues, including pituitary gland, adrenal gland, and testis. Low expression was found in other tissues such as heart, kidney, thymus, and skeletal muscle.