Kallikrein 11 (KLK11)

Kallikrein 11 is a member of the human kallikrein gene family. KLK11 is a secreted serine protease, highly expressed in hormonally regulated tissues, including the prostate and the ovary. KLK11 has two alternative splicing isoforms, known as the brain type and prostate type. Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers. KLK11 may represent a diagnostic and prognostic biomarker for ovarian cancer. KLK11 expression in prostate, testis, trachea, pancreas, salivary gland, thyroid, parathyroid, lung, stomach, and adult and fetal skin. Weaker expression was detected in heart, mammary gland, uterus, colon, and small intestine, with little to no expression in other tissues examined