Lysine Specific Demethylase 4C (KDM4C)

KDM4C encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.The transcript contains an MIR repetitive element in its 3-prime UTR, and the deduced 1,100-amino acid protein shares significant similarity with an S. cerevisiae zinc finger protein. RT-PCR ELISA detected JMJD2C expression in all tissues examined. Highest expression was in brain, and lowest was in skeletal muscle and spleen.