Lysophosphatidylcholine Acyltransferase 4 (LPCAT4)

Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction.The deduced 524-amino acid protein has a calculated molecular mass of 57.2 kD. It has a phosphate acyltransferase domain that shares 15 to 29% amino acid identity with the acyltransferase domains of other AGPATS and contains all the residues essential for acyltransferase activity. AGPAT7 expression in uterus, thymus, pancreas, skeletal muscle, bladder, stomach, lung, and testis. Fluorescence-tagged AGPAT7 showed a perinuclear and punctate distribution in transfected HeLa cells and colocalized with an endoplasmic reticulum marker.