Lysophosphatidylethanolamine Acyltransferase 1 (LPEAT1)

MBOAT1 shares structural similarity with a superfamily of membrane-bound O-acetyltransferases that transfer organic compounds, usually fatty acids, onto hydroxyl groups of membrane-embedded targets.The deduced 492-amino acid protein contains 9 putative transmembrane domains and a C-terminal endoplasmic reticulum (ER) retention motif (KKxx). RT-PCR detected high Lpeat1 expression in stomach, epididymis, and colon. Lpeat1 colocalized with an ER marker protein in transfected Chinese hamster ovary cells.deduced 495-amino acid protein contains 9 transmembrane domains, an extracellular N terminus, and an intracellular C terminus. MBOAT1 shares similarity with membrane-bound O-acetyltransferases, including conservation of polar residues within and adjacent to the membrane, and an invariant active site histidine at position 381.