MYST Histone Acetyltransferase 4 (MYST4)

MORF is a 1,781-residue protein that is ubiquitously expressed in adult human tissues. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at its C terminus, and may be involved in both positive and negative regulation of transcription.Genomic analyses revealed that the breaks were close to Alu elements in intron 16 of MORF and intron 2 of CBP and that duplications had occurred near the breakpoints.The authors constructed an exon/intron map of the MORF gene. The MORF-CBP protein retained the zinc fingers, 2 nuclear localization signals, the histone acetyltransferase (HAT) domain, a portion of the acidic domain of MORF, and the CBP protein downstream of codon 29.