Methyltransferase Like Protein 1 (METTL1)

METTL1 is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.The predominant transcript encodes a deduced 276-amino acid human METTL1 protein that shows high sequence similarity to putative proteins from mouse, Drosophila, A. thaliana, C. elegans, and yeast. Computer analyses of these proteins revealed 2 highly conserved amino acid motifs, one of which is an S-adenosylmethionine-binding domain typical of methyltransferases; the other motif has no known function.