Methyltransferase Like Protein 4 (METTL4)

METTL4 belongs to the MT-A70-like family. One subfamily is a small group of bacterial DNA: m6A MTases.  The  other three are paralogous eukaryotic lineages, two of which have not  been  associated  with  MTase  activity  but  include  proteins that regulate mRNA   levels   via   unknown  mechanisms  apparently  not  involving methylation. MT-A70-like proteins contain examples of some of the consensus methyltransferase motifs that have been derived from mutational and structural studies of   bacterial   DNA  methyltransferases,  including  the  universally conserved motif  IV catalytic residues and a proposed motif I element. METTL4 was mapped to 18p11.31, and the relationship between the SNPs and high myopia. The exons of METTL4 gene were analyzed by polymerase chain reaction, heteroduplex-single strand conformation polymorphism and sequencing.