Mps One Binder Kinase Activator Like Protein 2C (MOBKL2C)

MOBKL2C is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed.The MATS1 protein contains 216 amino acids and shares 87% identity with Drosophila Mats. Lai et al. (2005) described the growth inhibitory functions of Drosophila Mats. Loss of Mats function resulted in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth. Mats physically associated with Lats/Wts kinase (LATS1) and stimulated its catalytic activity, and this function was conserved in human MATS1. Furthermore, human MATS1 could rescue the lethality associated with loss of Mats function in Drosophila.