N-6-Adenine Specific DNA Methyltransferase 2 (N6AMT2)

N6AMT2, Belongs to the methyltransferase superfamily. AML1 family. N6AMT2is a 214 amino acid protein that is encoded by a gene located on human chromosome 13q12.11. A methyltransferase is a type of transferase enzyme that transfers a methyl group from a donor to an acceptor. Methytransferases use a reactive methyl group bound to sulfur in S-adenosyl methionine (SAM) as the methyl donor. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence, an example of epigenetic modification. This methylation occurs on cytosine residues. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice, they caused a recessive lethal phenotype.