N-Alpha-Acetyltransferase 10 (NaA10)

N-alpha-acetylation is one of the most common protein modifications that occurs during protein synthesis and involves the transfer of an acetyl group from acetyl-coenzyme A to the protein alpha-amino group. ARD1A, together with NATH (NARG1), is part of a major N-alpha-acetyltransferase complex responsible for alpha-acetylation of proteins and peptides.Three new genes were identified and positioned. One of these, termed TE2, demonstrated 40% identity with the ARD1 protein of Saccharomyces cerevisiae, a protein required for the expression of an N-terminal protein acetyltransferase activity.The 235-amino acid protein contains an N-acetyltransferase domain, a highly conserved acetyl-coenzyme A binding motif, and a C-terminal APP-binding domain.