NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 11 (NDUFa11)

NDUFA11 is a component of mitochondrial complex I. Complex I catalyzes the first step in the electron transport chain, the transfer of 2 electrons from NADH to ubiquinone, coupled to the translocation of 4 protons across the membrane.Carroll et al. (2002) cloned bovine Ndufa11, which they called B14.7, and identified human NDUFA11 by database analysis. The bovine and human proteins share 72% amino acid identity. The initiating methionine of the bovine protein is removed, and the deduced 140-amino acid mature protein has an acetylated N-terminal alanine and 4 possible transmembrane spans.Hartz (2009) mapped the NDUFA11 gene to chromosome 19p13.3 based on an alignment of the NDUFA11 sequence with the genomic sequence (build 36.1).