NADH Dehydrogenase Ubiquinone 1 Alpha Subcomplex 12 (NDUFa12)

NDUFa12 belongs to the complex I NDUFA12 subunit family. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase, that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The sequences of 41 subunits of complex I from bovine heart mitochondria have been described previously. Seven of them are encoded in mitochondrial DNA, and the remainder are nuclear gene products that are imported into the organelle from the cytoplasm.The cDNA sequence of this protein, determined with the aid of the peptide sequences, demonstrates that it is a novel subunit of complex I, and that it is related to a 13-kDa human protein associated with differentiation.