NADH Dehydrogenase Ubiquinone 1 Subcomplex 1 (NDUFC1)

The multisubunit NADH:ubiquinone oxidoreductase (complex I) is the first enzyme complex in the electron transport chain of mitochondria. Ton et al. (1997) isolated human heart cDNAs encoding CI-KFYI (NDUFC1) and 4 other complex I subunits. The predicted protein contains 76 amino acids.By radiation hybrid analysis, Mao et al. (1998) mapped the NDUFC1 gene to 4q28.2-q31.1. By radiation hybrid analysis, Emahazion et al. (1998) mapped the NDUFC1 gene to 4q28.2-q28.3. Smeitink and van den Heuvel (1999) reviewed the available molecular data regarding the human nuclear-encoded complex I subunits.