NADH Dehydrogenase Ubiquinone Flavoprotein 3 (NDUFV3)

NDUFV3 is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.The NDUFV3 gene was found to contain 3 exons, spanning 20 kb. The open reading frame contains a 34-codon import sequence and a 74-codon mature protein sequence. Its homology to bovine and rat protein sequence was found but not to any other known protein. Northern blot analysis showed that the NDUFV3 gene is ubiquitously expressed.