Neprilysin 2 (NEP2)

MMEL1 is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.Neprilysin-2 is a zinc protease of the Neprilysin family, Highly expressed in testis and nervous system, Both membrane-bound and soluble forms appear comparable with regard to model substrates, pH optima, and inhibitor profiles. Like the closely related Neprilysin, Neprilysin-2 substrates include Tachykinins and Enkephalins.