Non Metastatic Cells 6, Protein Expressed In (NME6)

Nucleoside diphosphate (NDP) kinases, such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. NME6 shows 34 to 41% amino acid sequence identity to other members of the NME family. It contains the conserved NDP kinase active site motif involved in phosphoryl transfer as well as other residues previously identified as crucial for nucleotide binding and catalysis. Compared to NME1 and NME2, NME6 has 3 additional residues located in the Kpn loop and a 22-residue extension at the C terminus. Northern blot analysis detected wide expression of a 1.3-kb transcript in human tissues, with highest expression in kidney, prostate, ovary, intestine, and spleen.