Obg Like ATPase 1 (OLA1)

OLA1 binds and hydrolyzes ATP more efficiently than GTP and thus is a member of a new subclass of NTPases in the Obg family of GTPases.members of this protein family from different species also have ATPase activity and are not exclusively GTPases. one cause of the altered nucleotide specificity of this subclass of NTPases is a substitution of a hydrophobic amino acid for a glutamine in all members of the Obg family. They noted that the same substitution inactivates Ras-like GTPases.The deduced 396-amino acid protein consists of an N-terminal G domain, flanked on either side by an inserted coiled-coil, and a C-terminal TGS domain.