Pancreatic Lipase Related Protein 3 (PNLIPRP3)

The DNA alterations on chromosome 9p24.3 and 10q25.3 are located in the intron 3 of DOCK8, and intron 4 of PNLIPRP3 loci, respectively. The expression levels of PNLIPRP3 and DOCK8 genes were further analyzed by LightCycler Instrument, with the specific primers designed using the Primer 3 program. PNLIPRP3 overexpression was significant in the chemotherapeutic patient group. Functions of this gene have been proposed to participate in a lipid metabolic process. Proteins are expected to have molecular functions in catalytic activity and triacylglycerol lipase activity, and to localize extracellularly. This may be the first report of a novel PNLIPRP3 over-expression in HCC. Although PNLIPRP3 over-expression in HCC was significant in the chemotherapeutic patient group, the therapeutic function of this gene for HCC patients should be studied further.