Peptidylprolyl Isomerase H (PPIH)

Peptidyl-prolyl cis-trans isomerase H is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP.This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.PPIH encodes a deduced 177-amino acid protein that shares 68% and 55% sequence identity with C. elegans CyP-11 and human cyclophilin A (PPIA), respectively.