Peroxisomal Biogenesis Factor 11 Beta (PEX11b)

The closest relative of the encoded human protein was the product of a second human gene; the authors designated the 2 human genes PEX11-alpha and PEX11-beta.The deduced 259-amino acid PEX11-beta protein shares approximately 20% amino acid identity with yeast Pex11. PEX11-beta has 2 predicted membrane-spanning domains, 1 at its C terminus and a second located approximately 100 amino acids from its N terminus. The termini of PEX11-beta are predicted to extend into the cytoplasm. Localization studies indicated that PEX11-beta is a peroxisomal protein. Northern blot analysis of rat tissues showed that Pex11-beta mRNA levels were similar in all tissues examined and were unaffected by peroxisome-proliferating agents.