Peroxisomal Biogenesis Factor 14 (PEX14)

PEX14 is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.In addition to the interaction with the PTS2 receptor, PEX14 protein was found to interact with PEX5 protein, the PTS1 receptor. This observation suggested the overlapping of 2 import pathways, with PEX14 being the point of convergence. Moreover, PEX14 also interacted with 2 other membrane-bound peroxins, including the SH3 domain protein PEX13, the putative docking protein for PTS1-dependent protein import.