Phosphatidylserine Decarboxylase (PISD)

Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunitsThe deduced protein contains at least 370 amino acids. Pisd was expressed in all mouse tissues examined, with highest expression in testis and liver. Expression was lower in embryonic and young mice compared with adult mice. Beta-galactosidase (GLB1) staining detected high Pisd expression in embryonic heart and in Sertoli cells of adult testis.