Phosphodiesterase 1A, Calmodulin Dependent (PDE1A)

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin -dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+).The predicted 535-amino acid PDE1A protein is 94% identical to the bovine 61-kD CaM-PDE when 2 short regions unique to PDE1A are excluded from comparison. Northern blot analysis revealed tissue-specific expression of 4.8-, 2.4-, and 2.6-kb PDE1A mRNAs, with transcripts most abundant in brain, heart, kidney, and skeletal muscle.