Phosphodiesterase 1B, Calmodulin Dependent (PDE1B)

Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are CaM-PDEs that are stimulated by a calcium-calmodulin complex.The deduced 516-amino acid protein differs from the 536-amino acid PDE1B1 protein only at its N terminus. Northern blot analysis detected PDE1B1 expression in several specific brain regions, particularly caudate nucleus and putamen, but not in spinal cord or any peripheral tissues. In contrast, PDE1B2 was highly expressed in spinal cord, with lower expression in thyroid, thymus, uterus, small intestine, putamen, and caudate nucleus.