Phosphodiesterase 9A (PDE9A)

Phosphodiesterase 9A(PDE9A) catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.Four different transcripts deriving from alternative splicing of 5-prime exons and containing the 3-prime,5-prime-cyclic nucleotide phosphodiesterase signature motif were identified. Northern blot analysis revealed several mRNA species of approximately 2.4 kb with varying expression patterns and intensities in all tissues examined except blood.