Phosphoglycerate Dehydrogenase Like Protein 1 (PHGDHL1)

3-Phosphoglycerate dehydrogenase catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor. The SNPs rs9513584 and rs4936742 located within the genes UBAC2 (ubiquitin-associated domain [UBA] containing 2) and UBASH3B (ubiquitin associated and SH3 domain containing, B) were also associated with Behçet"""s disease with P values of 5.8 × 10-3 and 1.5 × 10-3, respectively. However, the association between rs9513584 within UBAC2 and Behçet"""s disease is not significant after correction for multiple testing.However, the association between rs9513584 within UBAC2 and Behçet"""s disease is not significant after correction for multiple testing.