Phospholipase A2, Group X (PLA2G10)

The A2 phospholipases (PLA2s; EC 3.1.1.4) catalyze the release of fatty acids from phospholipids and play a role in a wide range of physiologic functions. Cupillard et al. (1997) cloned a novel secretory PLA2, termed GXSPLA2, from a human fetal lung cDNA library. The sequence encodes a 165-amino acid polypeptide, including the 42-amino acid signal peptide. Northern blot analysis revealed that GXSPLA2 expresses an 0.8-kb mRNA in pancreas, lung, and colon and a 1.5-kb mRNA in spleen, thymus, and peripheral blood leukocytes. Expression studies showed that the cDNA encodes an active phospholipase which was secreted into the culture medium.Cupillard et al. (1997) used in situ hybridization to map the PLA2G10 gene to human chromosome 16p13.1-p12.