Phosphoribosylglycinamide Formyltransferase (GART)

GART is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This C terminal-truncated human GARS protein is produced by alternative splicing resulting in the use of a polyadenylation site in the intron between the terminal GARS and the first AIRS exons. The expression of both the GARS and GARS-AIRS-GART proteins is regulated during development of the human cerebellum, while the expression of FGARAT appears to be constitutive. All 3 proteins were found to be expressed at high levels during normal prenatal development of the cerebellum, while the GARS and GARS-AIRS-GART proteins become undetectable in the cerebellum shortly after birth.