Polymerase DNA Directed Epsilon 2 (POLe2)

DNA polymerase epsilon (POLE) has been implicated in DNA repair and replication. Purified human HeLa POLE consists of a 261-kD catalytic subunit and a 55-kD accessory subunit. Li et al. (1997) cloned the small subunit of human POLE, which they symbolized DPE2. The cDNA predicted a 526-amino acid protein. The gene product has 26% identity to DPB2, a POLE accessory protein in the yeast S. cerevisiae.Li et al. (1997) assigned the DPE2 gene to human chromosome 14 using human-rodent hybrid panels. The gene was then regionally localized to 14q13-q21 by fluorescence in situ hybridization.