Prolyl tRNA Synthetase 2, Mitochondrial (PARS2)

By searching a database for tRNA synthetases, Bonnefond et al. (2005) identified PARS2, which they called MT-PRORS. The deduced 475-amino acid protein has a 47-amino acid mitochondrial targeting signal, resulting in a mature protein of 428 amino acids. PARS2 is a class II amino acid tRNA synthetase, with a C-terminal active-site domain linked to an N-terminal anticodon-binding domain by a short hinge. PARS2 shares no significant similarity with its cytosolic counterpart, EPRS.Bonnefond et al. (2005) determined that the PARS2 gene contains 1 exon and spans 1.4 kb. By genomic sequence analysis, Bonnefond et al. (2005) mapped the PARS2 gene to chromosome 1.