Proprotein Convertase Subtilisin/Kexin Type 4 (PCSK4)

Proprotein convertases, including PCSK4, are calcium-dependent serine proteases related to bacterial subtilisins and to yeast kexin. These enzymes process precursor proteins to their active forms by selective cleavage of the polypeptide at sites following paired basic amino acids. In mammals, this family comprises PC1, PC2, PC4, PC5, furin (FUR), and PACE4. Substrates for these enzymes range from prohormones to precursors for growth factors to cell surface receptors and viral surface glycoproteins.Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex.