Protease, Serine 48 (PRSS48)

PRSS48 belongs to the peptidase S1 family. Serine proteases are proteases in which one of the amino acids in the active site of the enzyme is serine.They are found in both single-cell and complex organisms, in both cells with nuclei and without nuclei.Serine proteases are grouped into clans that share structural similarities (homology) and are then further subgrouped into families with similar sequences.The major clans found in humans include the chymotrypsin-like, the subtilisin-like, the alpha/beta hydrolase, and signal peptidase clans.In evolutionary history, serine proteases were originally digestive enzymes. In mammals, they evolved by gene duplication to serve functions in blood clotting, the immune system, and inflammation.Serine proteases are paired with serine protease inhibitors, which turn off their activity when they are no longer needed.