Protease, Serine Like Protein 1 (PRSSL1)

PRSSL1, Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. PRSSL1 encodes a 30.14-kD secreted protein that shares 34 to 42% amino acid identity with several serine protease families. PRSSL1 is expressed in normal and immortalized nontumorigenic mammary epithelial cells but is reduced or absent in numerous human breast cancer cell lines. Thus, PRSSL1 may play a role in suppression of tumorigenesis.By fluorescence in situ hybridization, Polikoff et al. (1997) mapped the PRSSL1 gene to 19q13.3. Loss of heterozygosity studies on gliomas showed frequent allelic loss and a commonly deleted region at 19q13.2-q13.4, suggesting the presence of a tumor suppressor gene.